POLE mutations define a distinct ultramutated subtype of endometrial carcinoma associated with:

✓ Excellent prognosis

✓ Reduced risk of recurrence

✓ Improved risk stratification

✓ Potential treatment de-escalation in selected patients

Clinical Applications

Endometrial Carcinoma

• Molecular classification

• Prognostic assessment

• Risk stratification

• Treatment planning

Other Tumour’s of Relevance

• Colorectal carcinoma

• Brain tumours

• Ovarian carcinoma

• Other solid tumours

POLE + MSI + p53 – Complete Molecular Classification for Endometrial Cancer